Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus
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منابع مشابه
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus.
The hypothesis that dynamic actin filaments participate in specific aspects of synaptic plasticity was investigated at the Schaffer-collateral-CA1 pyramidal cell synapse of mouse hippocampus. Low concentrations (0.01-1 microM) of compounds that inhibit actin filament assembly were bath applied to hippocampal slices during extracellular recording of field excitatory postsynaptic potentials. Cyto...
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This reinforces the view (9) that the simple relations of quantal analysis do not necessarily hold in heterogeneous populations such as those found in the central nervous system. Addition of synapses with lower quantal size will, however, change the amplitude distribution of nonfailure responses, which was not observed in the above studies (1, 2). Nevertheless, detecting this change in distribu...
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Long-term potentiation (l.t.p.) was studied in area CA1 of rat hippocampal slices during development at post-natal days 1-8, 15 and 60. Tetanic stimulation at 100 Hz for 1 s was delivered to the fibres in stratum radiatum and the time course of potentiation was recorded in stratum pyramidale for 20 min after tetanus. L.t.p. was measured at 20 min post-tetanus as an increase in the amplitude of ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.100139797